circRNA basic information
circBase ID: -
Name: hsa_circ_PLCD1
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, PDX
Sample type details: NSCLC cells (NCI-H23, A549, SPC-A1, HCC827, NCI-H1299), normal HBE cells
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: circ-PLCD1, which was evidently downregulated in NSCLC tissues and cell lines. Circ-PLCD1 was transcriptionally activated by tumor-inhibiting protein p53, and exogenous expression of circ-PLCD1 inhibited NSCLC cell proliferation, invasion and induced apoptosis.
Molecular mechanism: circ-PLCD1 acted as a competitive endogenous RNA (ceRNA) to sponge hsa-miR-375 and hsa-miR-1179 and elevate PTEN, a well-known inhibitor of oncogenic PI3K/AKT signaling, thereby repressing NSCLC tumorigenesis. Importantly, we also identified this ceRNA regulatory axis of circ-PLCD1/hsa-miR-375/hsa-miR-1179/PTEN in vivo by establishing a xenograft tumor model. Clinically, NSCLC patients with low circ-PLCD1 expression had larger tumor size, later clinical stage and shorter survival time than those with high circ-PLCD1 expression.
Survival: poor
Supported No.:
 1
Description:

our findings reveal the important tumor suppressive role of circ-PLCD1 in NSCLC, reactivation of this circRNA may be considered as a novel therapeutic avenue for patient with NSCLC.
Other information
Title:

Circular RNA circ-PLCD1 functions as a tumor suppressor in non-small cell lung cancer by inactivation of PI3K/AKT signaling pathway.

Journal: Hum Cell
Published: 2022/3/19
PubMed ID: 35301686