circRNA basic information
circBase ID: -
Name: hsa_circ_ERBB2
Synonym: circERBB2
Host Gene: hsa-miR-98-5p
 
 
 
Disease basic information
DO ID:
 2841
DO name: asthma
Disease details: Asthma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Human airway smooth muscle cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IGF1R
Associated microRNA: hsa-miR-98-5p
Biological function: IGF1R_as identified as a target of_iR-98-5p, and knockdown of_GF1R_elieved the PDGF-BB-induced ASMCs proliferation and migration.
Molecular mechanism: CircERBB2_as identified to directly interact with_iR-98-5p, and overexpression of_iR-98-5p_bolished the function of_ircERBB2_n PDGF-BB-stimulated ASMCs.
Survival: -
Supported No.:
 1
Description:

Our work disclosed that knockdown of circERBB2 suppressed PDGF-BB-caused proliferation, migration and inflammatory response of ASMCs, through regulating miR-98-5p/IGF1R signaling, presented circERBB2 as a promising therapeutic target for asthma.
Other information
Title:

Circular RNA ERBB2 Contributes to Proliferation and Migration of Airway Smooth Muscle Cells via miR-98-5p/IGF1R Signaling in Asthma.

Journal: J Asthma Allergy
Published: 2021/10/8
PubMed ID: 34616159