circRNA basic information
circBase ID: -
Name: hsa_circ_ATG7
Synonym: circATG7
Host Gene: hsa-miR-766-5p
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: pancreatic epithelial cell lines (HPDE), PC cell line (AsPc-1, BXPC-3, Capan-2, CFPAC-1, PANC-1, MIA-PaCa2, SW1990)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-766-5p
Biological function: circATG7 overexpression promoted PC cell proliferation, mobility, and autophagy in vitro, while circATG7 knockdown induced the opposite effects.
Molecular mechanism: Cytoplasmic circATG7 sponged hsa-miR-766-5p and decreased its expression, and increased the expression of ATG7, a target gene of hsa-miR-766-5p.
Survival: -
Supported No.:
 1
Description:

In conclusion, our results demonstrated that circATG7 accelerates PC progression via miR-766-5p/ATG7 and that HUR/ATG7 depends on autophagic flux. Thus, circATG7 may be a potential therapeutic target for PC.
Other information
Title:

Autophagy-associated circRNA circATG7 facilitates autophagy and promotes pancreatic cancer progression.

Journal: Cell Death Dis
Published: 2022/3/16
PubMed ID: 35288538