circRNA basic information
circBase ID: hsa_circ_0087352
Name: hsa_circ_UBQLN1
Synonym: circ_0087352
Host Gene: hsa-miR-149-5p
 
 
 
Disease basic information
DO ID:
 7693
DO name: abdominal aortic aneurysm
Disease details: abdominal aortic aneurysm
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: THP-1 cells ,HA-VSMC cells ,VSMCs
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-149-5p
Biological function: hsa_circ_0087352 overexpression in macrophages induces human vascular smooth muscle cells (VSMC) apoptosis in macrophage-VSMC coculture system via the release of proapoptotic cytokines, such as IL-6, TNF-alpha and IL-1beta.
Molecular mechanism: hsa_circ_0087352 directly binds to hsa-miR-149-5p.
Survival: -
Supported No.:
 1
Description:

Overall, this study provides experimental evidence that hsa_circ_0087352 can be used as a new biomarker and therapeutic target for abdominal aortic aneurysm.
Other information
Title:

Hsa_circ_0087352 promotes the inflammatory response of macrophages in abdominal aortic aneurysm by adsorbing hsa-miR-149-5p.

Journal: Int Immunopharmacol
Published: 2022/3/15
PubMed ID: 35286916