circRNA basic information
circBase ID: -
Name: hsa_circ_ZKSCAN1
Synonym: circZKSCAN1
Host Gene: hsa-miR-1294
 
 
 
Disease basic information
DO ID:
 4467
DO name: clear cell renal cell carcinoma
Disease details: clear cell renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: ccRCC cells, 293_ cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1294
Biological function: CircZKSCAN1 knockdown significantly inhibited cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition of renal cell carcinoma (RCC) cells, whereas potentiated Natural Killer (NK) cell-mediated cytotoxicity against RCC cells_n vitro_nd repressed tumor growth_n vivo.
Molecular mechanism: circZKSCAN1/hsa-miR-1294/PIM1
Survival: -
Supported No.:
 1
Description:

we identified a novel circZKSCAN1/miR-1294/PIM1 axis was identified in RCC progression, showing that the expression of circZKSCAN1 expression in RCC cells was transcriptionally regulated by Kruppel-like factor 2. The results of our study may provide new insights for ccRCC basic research.
Other information
Title:

KLF2-induced circZKSCAN1 potentiates the tumorigenic properties of clear cell renal cell carcinoma by targeting the miR-1294/PIM1 axis.

Journal: Cell Cycle
Published: 2022/3/15
PubMed ID: 35285410