circRNA basic information
circBase ID: hsa_circ_0001666
Name: hsa_circ_FAM120B
Synonym: circ_0001666
Host Gene: hsa-miR-1184, hsa-miR-548I
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: immortalized human bronchial epithelial cells (BEAS-2B), human lung cancer cell lines (A549, H1299, H322, HCC2279)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1184, hsa-miR-548I
Biological function: circ0001666 could promote migration and invasion of NSCLC cells_n vitro_nd_n vivo.
Molecular mechanism: circ0001666 could act as a sponge to hsa-miR-1184/hsa-miR-548I and upregulate the expression of AGO1
Survival: poor
Supported No.:
 2
Description:

Collectively, these findings demonstrated that circ0001666 could serve as an oncogene to promote the migration and invasion of NSCLC via a novel miR-1184/miR-548I/AGO1 axis, which might be a promising therapeutic target for NSCLC treatment.
Other information
Title:

Hsa_circ_0001666 promotes non-small cell lung cancer migration and invasion through miR-1184/miR-548I/AGO1 axis.

Journal: Mol Ther Oncolytics
Published: 2022/3/15
PubMed ID: 35284630