circRNA basic information
circBase ID: hsa_circ_0000228
Name: -
Synonym: Circ_0000228
Host Gene: hsa-miR-337-3p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human cervical epithelial cells (HUCECs), CC cell lines (SiHa, HeLa, CaSKi, C33A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-337-3p
Biological function: Circ_0000228_verexpression markedly enhanced cell proliferation, migration, and invasion, while knocking down_irc_0000228_emarkably repressed cell proliferation, migration, and invasion.
Molecular mechanism: hsa-miR-337-3p_ould be adsorbed by_irc_0000228._GFBR1_as identified as a target gene of_iR-337-3p_hat indirectly and positively modulated bycirc_0000228_n the CC cells.
Survival: -
Supported No.:
 2
Description:

Circ_0000228_p-modulates_GFBR1_y targeting_iR-337-3p_o enhance CC cell proliferation, migration and invasion. Also,_irc_0000228_s a promising therapeutic target for the CC.
Other information
Title:

Circ_0000228 Promotes Cervical Cancer Progression via Regulating miR-337-3p /TGFBR1 Axis.

Journal: Cell J
Published: 2022/3/14
PubMed ID: 35279965