circRNA basic information
circBase ID: hsa_circ_0061825
Name: hsa_circ_TFF1
Synonym: Circ-TFF1
Host Gene: hsa-miR-129-2-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: MDA-MB-361, SK-Br-3 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-129-2-3p
Biological function: Silencing of circ-TFF1 reduced the proliferation, migration, invasion and tube formation, while increased the apoptosis
Molecular mechanism: hsa-miR-129-2-3p was a target of circ-TFF1. Silencing of circ-TFF1 inhibited the malignant behavior of BC cells by releasing hsa-miR-129-2-3p. In addition, IRAK1 was a target of hsa-miR-129-2-3p.
Survival: poor
Supported No.:
 3
Description:

Circ-TFF1 regulated the expression of IRAK1 by sponging miR-129-2-3p, thereby, promoting the development of BC. These data provided a novel targeted therapy for BC.
Other information
Title:

Circ-TFF1 Promotes Breast Cancer Progression Through the miR-129-2-3p/IRAK1 Axis.

Journal: Biochem Genet
Published: 2022/3/14
PubMed ID: 35279761