circRNA basic information
circBase ID: -
Name: hsa_circ_OPHN1
Synonym: Circ-OPHN1
Host Gene: hsa-miR-558
 
 
 
Disease basic information
DO ID:
 10591
DO name: pre-eclampsia
Disease details: preeclampsia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human extravillous trophoblast cell lines (JEG_3, HTR_8/SVneo)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-558
Biological function: Circ-OPHN1 or THBS2 overexpression hindered the proliferation, migration, and invasion of trophoblast cells.
Molecular mechanism: circ-OPHN1 sequestered hsa-miR-558 to regulate THBS2 expression,
Survival: -
Supported No.:
 1
Description:

Circ-OPHN1 inhibited trophoblast cell proliferation, migration, and invasion through mediating miR-558/THBS2 axis, providing a novel pathway for PE pathogenesis.
Other information
Title:

Circ-OPHN1 suppresses the proliferation, migration, and invasion of trophoblast cells through mediating miR-558/THBS2 axis.

Journal: Drug Dev Res
Published: 2022/3/13
PubMed ID: 35277867