circRNA basic information
circBase ID: hsa_circ_0003146
Name: -
Synonym: Circ_0003146
Host Gene: hsa-miR-1272
 
 
 
Disease basic information
DO ID:
 4467
DO name: clear cell renal cell carcinoma
Disease details: clear cell renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human ccRCC cell lines (786-O, caKi-1, A498, 769P), kidney epithelial cell line (HK-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1272
Biological function: Downregulation of circ_0003146 induced inhibition of proliferation, migration, invasion and EMT but the promotion of apoptosis in ccRCC cells. Tumor growth in vivo was inhibited after knockdown of circ_0003146.
Molecular mechanism: circ_0003146 regulated SCARB1 level by absorbing hsa-miR-1272.
Survival: -
Supported No.:
 2
Description:

The regulation of circ_0003146 in ccRCC progression was achieved by upregulating SCARB1 in part. The current findings demonstrated that circ_0003146 contributed to the malignant progression of ccRCC via inducing SCARB1 upregulation by targeting miR-1272.
Other information
Title:

Circ_0003146 upregulates SCARB1 expression by acting as a miR-1272 sponge to promote malignant behaviors of clear cell renal cell carcinoma.

Journal: Anticancer Drugs
Published: 2022/3/12
PubMed ID: 35276698