circRNA basic information
circBase ID: -
Name: hsa_circ_SAMD4A
Synonym: circSAMD4A
Host Gene: hsa-miR-545-3p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human CRC cell lines (SW480, HCT-116), their 5-Fu_resistant cells line (SW480/5-Fu, HCT-116/5-Fu)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-545-3p
Biological function: circSAMD4A knockdown inhibited the proliferation and glycolysis mechanism but promoted apoptosis in 5-Fu-resistant cells of CRC.
Molecular mechanism: circSAMD4A was identified as a molecular sponge of hsa-miR-545-3p to upregulate PFKFB3 expression.
Survival: -
Supported No.:
 1
Description:

CircSAMD4A contributed to 5-Fu resistance of CRC cells partly through upregulating PFKFB3 expression by sponging miR-545-3p, providing a possible circRNA-targeted therapy for CRC.
Other information
Title:

Circular RNA sterile alpha motif domain containing 4A contributes to cell 5-fluorouracil resistance in colorectal cancer by regulating the miR-545-3p/6-phosphofructo-2-kinase/fructose-2,6-bisphosphataseisotype 3 axis.

Journal: Anticancer Drugs
Published: 2022/3/12
PubMed ID: 35276696