circRNA basic information
circBase ID: hsa_circ_0119412
Name: hsa_circ_PER2
Synonym: circ_0119412
Host Gene: hsa-miR-217
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human cervical epithelial cells (HcerEpic), cervical cell line (CaSki), cervical cell lines (Hela, SiHa, C33A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-217
Biological function: circ_0119412 overexpression aggravated cervical cancer cell proliferation, migration, and adhesion, and its overexpression was also conducive to tumor formation and growth in animal models.
Molecular mechanism: AGR2 was upregulated in cervical cancer by the public bioinformatics data. circ_0119412 bound to hsa-miR-217, and hsa-miR-217 bound to AGR 3UTR.
Survival: -
Supported No.:
 1
Description:

circ_0119412 functioned as an oncogenic driver to promote the malignant development of cervical cancer by targeting the miR-217/AGR2 pathway.
Other information
Title:

hsa_circ_0119412 overexpression promotes cervical cancer progression by targeting miR-217 to upregulate anterior gradient 2.

Journal: J Clin Lab Anal
Published: 2022/3/12
PubMed ID: 35274779