circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: circITCH
Host Gene: hsa-miR-660
 
 
 
Disease basic information
DO ID:
 1909
DO name: melanoma
Disease details: melanoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human melanoma cell lines (WM_115, A_375)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-660
Biological function: Function study showed that circITCH suppressed melanoma cell proliferation and metastasis.
Molecular mechanism: The mechanism study showed that circITCH-sponged hsa-miR-660 to upregulate TFCP2 and suppress melanoma progression.
Survival: -
Supported No.:
 2
Description:

The circITCH/miR-660/TFCP2 axis is involved in melanoma progression hence circITCH can be a diagnostic biomarker as well as a target for treating melanoma.
Other information
Title:

circITCH suppresses cell proliferation and metastasis through miR-660/TFCP2 pathway in melanoma.

Journal: Cancer Med
Published: 2022/3/12
PubMed ID: 35274492