circRNA basic information
circBase ID: -
Name: hsa_circ_LRP1B
Synonym: Circ-LRP1B
Host Gene: hsa-miR-34a-5p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human C28/I2 chondrocytes
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-34a-5p
Biological function: Enforced expression of circ-LRP1B promoted cell proliferation, and repressed apoptosis and oxidative stress
Molecular mechanism: Circ-LRP1B acted as a competing endogenous RNA (ceRNA) for hsa-miR-34a-5p to involve the post-transcriptional regulation of NRF1 expression.
Survival: -
Supported No.:
 1
Description:

These findings demonstrate that circ-LRP1B functions as a ceRNA to regulate the proliferation, apoptosis and oxidative stress of LPS-stimulated human C28/I2 chondrocytes by miR-34a-5p/NRF1 network.
Other information
Title:

Circ-LRP1B functions as a competing endogenous RNA to regulate proliferation, apoptosis and oxidative stress of LPS-induced human C28/I2 chondrocytes.

Journal: J Bioenerg Biomembr
Published: 2022/3/12
PubMed ID: 35274224