circRNA basic information
circBase ID: hsa_circ_0098181
Name: hsa_circ_SOX5
Synonym: Circ_0098181
Host Gene: hsa-miR-18a-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human hepatoma cell lines (Huh7, Hep3B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-18a-3p
Biological function: After hsa_circ_0098181 was upregulated, the proliferation, invasion, migration, and colony formation of HCC cell lines were inhibited, and the apoptosis was promoted
Molecular mechanism: The dual-luciferase reporter assay and the RIP assay verified that hsa_circ_0098181 sponged hsa-miR-18a-3p to regulate PPARA.
Survival: better
Supported No.:
 3
Description:

In conclusion, hsa_circ_0098181 can repress the development of HCC through sponging miR-18a-3p and promoting the expression of PPARA_n vitro_nd_n vivo, and hsa_circ_0098181 might be a therapeutic target for HCC.
Other information
Title:

Hsa_Circ_0098181 Suppresses Hepatocellular Carcinoma by Sponging miR-18a-3p and Targeting PPARA.

Journal: Front Pharmacol
Published: 2022/3/11
PubMed ID: 35264957