circRNA basic information
circBase ID: -
Name: hsa_circ_ANKIB1
Synonym: circ_ANKIB1
Host Gene: hsa-miR-26b-5p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal osteoblast cell (hFOB1.19), human OS cell lines (KHOS, U2-OS)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-26b-5p
Biological function: circ_ANKIB1 silencing elevated miR-26b-5p, repressed EZH2, MRP1, P-gp, LRP, IC50, and elevated OS advancement.
Molecular mechanism: circ_ANKIB1 bind hsa-miR-26b-5p. Reduced hsa-miR-26b-5p revered the influence of silencing circ_ANKIB1 on DXR resistant OS cells. hsa-miR-26b-5p targeted EZH2, and EZH2 elevation reversed the impact of increasing hsa-miR-26b-5p on DXR resistant cells.
Survival: -
Supported No.:
 3
Description:

In conclusion, Circ_ANKIB1 binds miR-26b-5p and modulates EZH2 to accelerate the chemo-resistance of osteosarcoma.
Other information
Title:

Circular RNA_ANKIB1 accelerates chemo-resistance of osteosarcoma via binding microRNA-26b-5p and modulating enhancer of zeste homolog 2.

Journal: Bioengineered
Published: 2022/3/11
PubMed ID: 35264070