circRNA basic information
circBase ID: hsa_circ_0000418
Name: hsa_circ_CCT2
Synonym: circ_0000418
Host Gene: hsa-miR-409-3p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: astrocyte cell line (NHA), human glioma cell lines (U-87_G, U-138_G, U-118_G, T98-G, LN-229, LN-18)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-409-3p
Biological function: Circ_0000418 overexpression facilitated glioma cell growth and accelerated cell cycle progression, while knockdown of circ_0000418 produced the opposite effects.
Molecular mechanism: Circ_0000418 specifically combined with hsa-miR-409-3p, and circ_0000418 negatively modulated the expression of hsa-miR-409-3p. PDK1 acted as a target gene of hsa-miR-409-3p, and PDK1 could be positively and indirectly modulated by circ_0000418 in glioma cells.
Survival: -
Supported No.:
 1
Description:

In summary, circ_0000418 enhances glioma cell growth and accelerates cell cycle progression by regulating miR-409-3p/PDK1 axis.
Other information
Title:

Hsa_circ_0000418 promotes the progression of glioma by regulating microRNA-409-3p / pyruvate dehydrogenase kinase 1 axis.

Journal: Bioengineered
Published: 2022/3/11
PubMed ID: 35264067