circRNA basic information
circBase ID: hsa_circ_0001679
Name: -
Synonym: circ_0001679
Host Gene: hsa-miR-338-3p
 
 
 
Disease basic information
DO ID:
 850
DO name: lung disease
Disease details: lung injury
Species: human
Species details: human
Sample type: cell line
Sample type details: MLE-12 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-338-3p
Biological function: silencing circ_0001679 attenuated the growth inhibition and suppressed apoptosis induced by LPS.
Molecular mechanism: We further revealed that circ_0001679 functioned as a sponge of hsa-miR-338-3p to negatively regulate hsa-miR-338-3p activity. hsa-miR-338-3p downregulated its downstream target MAPK1, while the upregulation of circ_0001679 maintained a high-level expression of MAPK1 by suppressing hsa-miR-338-3p.
Survival: -
Supported No.:
 1
Description:

Collectively, our study indicates that circ_0001679/miR-338-3p/MAPK1 axis may play an important role in the pathogenesis of acute lung injury (ALI).
Other information
Title:

Knockdown of circ_0001679 alleviates lipopolysaccharide-induced MLE-12 lung cell injury by regulating the miR-338-3p/ mitogen-activated protein kinase 1 axis.

Journal: Bioengineered
Published: 2022/3/11
PubMed ID: 35264058