circRNA basic information
circBase ID: -
Name: hsa_circ_UBAP2
Synonym: circUBAP2
Host Gene: hsa-miR-300
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human TNBC cell lines (HCC1937, BT-549, MDA-MB-436), normal human breast epithelial cell line (MCF10A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-300
Biological function: TNBC sensitivity to DDP could be enhanced by silencing of circUBAP2.
Molecular mechanism: circUBAP2 was revealed to be a ceRNA for hsa-miR-300 to upregulate the expression of anti-silencing function 1B histone chaperone (ASF1B).
Survival: -
Supported No.:
 1
Description:

In summary, this research revealed a novel regulatory mechanism that circUBAP2 functioned as ceRNA of miR-300 to upregulate ASF1B, which further triggered the PI3K/AKT/mTOR (PAM) signaling to enhance the DDP resistance of TNBC.
Other information
Title:

Circular RNA UBAP2 facilitates the cisplatin resistance of triple-negative breast cancer via microRNA-300/anti-silencing function 1B histone chaperone/PI3K/AKT/mTOR axis.

Journal: Bioengineered
Published: 2022/3/10
PubMed ID: 35263216