circRNA basic information
circBase ID: -
Name: hsa_circ_TADA2A
Synonym: circTADA2A
Host Gene: hsa-miR-450b-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: A549, H1299 cells.
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGN5
Associated microRNA: hsa-miR-450b-3p
Biological function: Functionally, circTADA2A inhibition successfully suppressed the proliferation, invasion, and migration of A549 and H1299 cells.
Molecular mechanism: circTADA2A functioned as a competing endogenous RNA to sponge hsa-miR-450b-3p to promote the expression of HMGN5 mRNA and protein.
Survival: poor
Supported No.:
 6
Description:

These findings suggest that circTADA2A might act as an oncogenic circRNA that promotes NSCLC progression by sponging miR-450b-3p and promoting HMGN5 expression, indicating that the suppression of circTADA2A could become a potential therapeutic target for restraining NSCLC.
Other information
Title:

Circular RNA circTADA2A promotes the proliferation, invasion, and migration of non-small cell lung cancer cells via the miR-450b-3p/HMGN5 signaling pathway.

Journal: Transl Cancer Res
Published: 2022/3/10
PubMed ID: 35261900