circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF652
Synonym: circZNF652
Host Gene: hsa-miR-486-5p
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal human astrocyte (NHA), human GBM cell lines (A172, U251, LN229, U87)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-486-5p
Biological function: Silencing of circZNF652 and miR-486-5p overexpression suppressed cell growth, migration, invasion, epithelial-mesenchymal transition (EMT) and tumorigenesis in GBM cells_n vitro_nd_n vivo.
Molecular mechanism: circZNF652 sponged hsa-miR-486-5p to upregulate SERPINE1 in GBM cells.
Survival: -
Supported No.:
 1
Description:

Collectively, we concluded that targeting the circular RNA circZNF652/miR-486-5p/SERPINE1 axis was a novel and effective strategy to suppress cancer progression in GBM.
Other information
Title:

Identification of a novel circular RNA circZNF652/miR-486-5p/SERPINE1 signaling cascade that regulates cancer aggressiveness in glioblastoma (GBM).

Journal: Bioengineered
Published: 2022/3/9
PubMed ID: 35258403