circRNA basic information
circBase ID: hsa_circ_0081241
Name: hsa_circ_TRRAP
Synonym: circTRRAP
Host Gene: hsa-miR-370-3p
 
 
 
Disease basic information
DO ID:
 5844
DO name: myocardial infarction
Disease details: acute myocardial infarction
Species: human
Species details: human
Sample type: cell line
Sample type details: Human cardiomyocyte AC16
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PAWR
Associated microRNA: hsa-miR-370-3p
Biological function: Downregulation of circTRRAP promoted cell growth but inhibited apoptosis, inflammation, and oxidative stress in hypoxic cells.
Molecular mechanism: CircTRRAP could target miR-370-3p, and the regulatory effects of circTRRAP on the hypoxic cells were associated with the sponge function of miR-370-3p. PAWR served as the target for miR-370-3p, and it was regulated by circTRRAP/miR-370-3p axis.
Survival: -
Supported No.:
 1
Description:

These findings demonstrated that silence of circTRRAP exerted the protection against the hypoxia-induced damages in cardiomyocytes through regulating the miR-370-3p and PAWR levels.
Other information
Title:

CircTRRAP Knockdown Has Cardioprotective Function in Cardiomyocytes via the Signal Regulation of miR-370-3p/PAWR Axis.

Journal: Cardiovasc Ther
Published: 2022/3/8
PubMed ID: 35251305