circRNA basic information
circBase ID: hsa_circ_0000591
Name: -
Synonym: Circ_0000591
Host Gene: hsa-miR-326
 
 
 
Disease basic information
DO ID:
 4947
DO name: cholangiocarcinoma
Disease details: cholangiocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human CCA cell lines (CCLP-1, HUCCT1, RBE), normal biliary cell line (HIBEpiC), KMBC, HCCC-9810
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-326
Biological function: The highly expressed circ_0000591 could promote the proliferation, migration, invasion and carcinogenesis of CCA cells in vitro and in vivo.
Molecular mechanism: circ_0000591 induced the proliferation, migration and invasion of CCA cells through sponging hsa-miR-326.
Survival: -
Supported No.:
 1
Description:

In conclusion, this study revealed a novel regulatory mechanism that circ_0000591 contributed to the progression of CCA via miR-326/TLR4/MyD88/IL6 axis. These findings enhanced our knowledge of potential molecular mechanism involved in the malignant progression of CCA.
Other information
Title:

Circ_0000591 served as endogenous RNA for miR-326 to promote progression of cholangiocarcinoma via the TLR4/MyD88/IL6 axis.

Journal: Biochem Biophys Res Commun
Published: 2022/3/7
PubMed ID: 35248826