circRNA basic information
circBase ID: hsa_circ_0012138
Name: hsa_circ_ERI3
Synonym: -
Host Gene: hsa-miR-7682-3p
 
 
 
Disease basic information
DO ID:
 0050855
DO name: renal fibrosis
Disease details: renal fibrosis
Species: human
Species details: human
Sample type: PDX
Sample type details: BUMPT cells
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-7682-3p
Biological function: attenuated fibrotic lesions in the kidneys of UUO mice via targeting miR-7682-3p/Fgb axis
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

In conclusion, we for the first time demonstrated that circRNA_37492 attenuated renal fibrosis via targeting miR-7682-3p/Fgb axis, and the homologous hsa_circRNA_0012138 was speculated as a possible ceRNA to regulate multiple gene expressions and involve in human renal fibrosis, suggesting that circRNA_37492/hsa_circ_0012138 may serve as potent therapy target for obstructive renal fibrosis disease.
Other information
Title:

The mmu_circRNA_37492/hsa_circ_0012138 function as potential ceRNA to attenuate obstructive renal fibrosis.

Journal: Cell Death Dis
Published: 2022/3/6
PubMed ID: 35246505