circRNA basic information
circBase ID: hsa_circ_0000277
Name: hsa_circ_PDE3B
Synonym: -
Host Gene: hsa-miR-873-5p
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human esophageal epithelial cell line (HET-1A), ESCC cell lines (EC9706, KYSE30)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-873-5p
Biological function: Downregulation of hsa_circ_0000277 repressed ESCC cell proliferation, colony formation, cell cycle, and DDP resistance.
Molecular mechanism: Hsa_circ_0000277 acted as a microRNA-873-5p (hsa-miR-873-5p) sponge and Sry-related high-mobility group box 4 (SOX4) was validated as a target of hsa-miR-873-5p.
Survival: -
Supported No.:
 3
Description:

These findings unraveled that hsa_circ_0000277 promoted ESCC progression and DDP resistance via miR-873-5p/SOX4/Wnt/beta-catenin axis, showing a specific molecular mechanism of carcinogenesis and chemoresistance in ESCC.
Other information
Title:

Circular RNA hsa_circ_0000277 promotes tumor progression and DDP resistance in esophageal squamous cell carcinoma.

Journal: BMC Cancer
Published: 2022/3/5
PubMed ID: 35241028