circRNA basic information
circBase ID: hsa_circ_0028007
Name: -
Synonym: Circ_0028007
Host Gene: hsa-miR-656-3p
 
 
 
Disease basic information
DO ID:
 9261
DO name: nasopharynx carcinoma
Disease details: nasopharyngeal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal nasopharyngeal epithelial cell line (NP69), NPC cell lines (SUNE-1, C666-1, 5-8F)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-656-3p
Biological function: Knockdown of circ_0028007 repressed NPC cell growth, migration, invasion, and angiogenesis, facilitated apoptosis in vitro and blocked tumor growth in vivo.
Molecular mechanism: circ_0028007 promoted the malignant behaviors of NPC cells via acting as hsa-miR-656-3p sponge. In addition, ELF2 was demonstrated to be the target gene of hsa-miR-656-3p.
Survival: -
Supported No.:
 1
Description:

Circ_0028007 contributed to the progression of NPC by decoying miR-656-3p and elevating ELF2. The findings might provide potential targets for NPC therapy.
Other information
Title:

Circ_0028007 Aggravates the Malignancy of Nasopharyngeal Carcinoma by Regulating miR-656-3p/ELF2 Axis.

Journal: Biochem Genet
Published: 2022/3/4
PubMed ID: 35239093