circRNA basic information
circBase ID: hsa_circ_0008500
Name: -
Synonym: Circ_0008500
Host Gene: hsa-miR-758-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal breast epithelial cell line (MCF-10A), normal breast cancer cell line (MDA-MB-468, MCF-7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-758-3p
Biological function: The results showed that circ_0008500 knockdown inhibited cell growth, and facilitated cell apoptosis and radiosensitivity in breast cancer cells in vitro.
Molecular mechanism: circ_0008500 regulated PFN2 expression by sponging hsa-miR-758-3p.
Survival: -
Supported No.:
 1
Description:

In conclusion, circ_0008500 inhibition promoted the radiosensitivity and restrained the development of breast cancer by downregulating PFN2 expression via targeting miR-758-3p.
Other information
Title:

Circ_0008500 Knockdown Improves Radiosensitivity and Inhibits Tumorigenesis in Breast Cancer Through the miR-758-3p/PFN2 Axis.

Journal: J Mammary Gland Biol Neoplasia
Published: 2022/3/4
PubMed ID: 35239064