circRNA basic information
circBase ID: hsa_circ_0076305
Name: -
Synonym: Circ_0076305
Host Gene: hsa-miR-411-5p
 
 
 
Disease basic information
DO ID:
 10283
DO name: prostate cancer
Disease details: prostate cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: PCa cells (DU145,PC3, VCaP), human prostate epithelial cells (RWPE-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-411-5p
Biological function: Circ_0076305 silencing could repress cell growth, migration and glycolysis while triggered apoptosis in PCa cells.
Molecular mechanism: hsa-miR-411-5p was targeted by circ_0076305, and hsa-miR-411-5p suppression counteracted the influence of circ_0076305 silencing in PCa cells.hsa-miR-411-5p directly targeted PGK1, and hsa-miR-411-5p upregulation restrained PCa cell malignant behaviours via reducing PGK1.circ_0076305 sponged hsa-miR-411-5p to affect PGK1 expression.
Survival: -
Supported No.:
 1
Description:

Circ_0076305 served as a novel oncogene PCa progression through regulation of miR-411-5p/PGK1 axis.
Other information
Title:

Circ_0076305 facilitates prostate cancer development via sponging miR-411-5p and regulating PGK1.

Journal: Andrologia
Published: 2022/3/4
PubMed ID: 35238066