circRNA basic information
circBase ID: -
Name: hsa_circ_FAM126A
Synonym: circFAM126A
Host Gene: hsa-miR-186
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: OSCC cell lines (CAL27, SCC25, SCC15, TSCCA, UM1, UM2), normal human oral epithelial cells (NHOK), HEK-293 T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-186
Biological function: knockdown of circFAM126A markedly suppressed the proliferation, migration, and invasion of OSCC cells_n vitro_nd inhibited tumor growth and distant metastasis_n vivo.
Molecular mechanism: circFAM126A increased the expression of RAB41 and promoted its mRNA stability_ia_inding to hsa-miR-186 and RNA-binding protein FUS. Overexpression of RAB41 antagonized the effects of circFAM126A knockdown and induced an aggressive phenotype of OSCC cells.
Survival: -
Supported No.:
 2
Description:

SP1 transcriptionally activated circFAM126A modulated the growth, epithelial-mesenchymal transition (EMT) of OSCC cells_ia_argeting the miR-186/FUS/RAB41 axis, suggesting that circFAM126A is a potential biomarker for the treatment of OSCC.
Other information
Title:

SP1-Mediated Upregulation of circFAM126A Promotes Proliferation and Epithelial-Mesenchymal Transition of Oral Squamous Cell Carcinoma via Regulation of RAB41.

Journal: Front Oncol
Published: 2022/3/4
PubMed ID: 35237504