circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF609
Synonym: CircZNF609
Host Gene: hsa-miR-134-5p
 
 
 
Disease basic information
DO ID:
 2876
DO name: laryngeal squamous cell carcinoma
Disease details: laryngeal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human LSCC cell lines (TU177, TU686, TU212, LSC-1, Hep-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-134-5p
Biological function: Knockdown of circZNF609 inhibited LSCC proliferation, invasion and the expression of PCNA and matrix
Molecular mechanism: CircZNF609 can regulate hsa-miR-134-5p to upregulate epidermal growth factor receptor (EGFR).
Survival: poor
Supported No.:
 1
Description:

CircZNF609 promotes the progression of LSCC via the miR-134-5p/EGFR axis, which might be the therapeutic target of LSCC.
Other information
Title:

Circular RNA ZNF609 promotes laryngeal squamous cell carcinoma progression by upregulating epidermal growth factor receptor via sponging microRNA-134-5p.

Journal: Bioengineered
Published: 2022/3/4
PubMed ID: 35236250