circRNA basic information
circBase ID: -
Name: hsa_circ_PTK2
Synonym: circPTK2
Host Gene: hsa-miR-136
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: TNBC cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-136
Biological function: CircPTK2 significantly promoted the proliferation, migration, and invasion of TNBC cells.
Molecular mechanism: CircPTK2 was confirmed to be a sponge of hsa-miR-136, and directly regulated NFBI and AKT/PI3K pathway. A rescue assay validated circPTK2/hsa-miR-136/NFIB axis in TNBC cells.
Survival: -
Supported No.:
 2
Description:

CircPTK2 promoted TNBC progression and development. circPTK2/miR-136/NFIB might be an effective biomarker for TNBC.
Other information
Title:

Circular RNA circPTK2 modulates migration and invasion via miR-136/NFIB signaling on triple-negative breast cancer cells in vitro.

Journal: Inflamm Res
Published: 2022/3/3
PubMed ID: 35234989