circRNA basic information
circBase ID: -
Name: hsa_circ_REEP3
Synonym: circREEP3
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: colorectal cancer cell lines
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: circREEP3 knockout suppresses CRC tumorigenesis and metastasis, and impairs stem cell-like phenotype.
Molecular mechanism: circREEP3 recruits the chromatin remodeling protein CHD7 to FKBP10 promoter and activates its transcription. Moreover, circREEP3 restricts RIG-1-dependent antitumor immunity.
Survival: poor
Supported No.:
 1
Description:

circREEP3-FKBP10 axis drives CRC progression and may be a critical prognostic marker.
Other information
Title:

circREEP3 Drives Colorectal Cancer Progression via Activation of FKBP10 Transcription and Restriction of Antitumor Immunity.

Journal: Adv Sci (Weinh)
Published: 2022/3/3
PubMed ID: 35233964