circRNA basic information
circBase ID: -
Name: hsa_circ_AKT3
Synonym: circ_AKT3
Host Gene: hsa-miR-206
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: MKN-7/DDP, HGC-27/DDP cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-206
Biological function: circ_AKT3 knockdown or miR-206 overexpression decreased the level of P-gp and IC50_f cisplatin and increased apoptosis of MKN-7/DDP and HGC-27/DDP cells.
Molecular mechanism: PTPN14 was regulated by circ_AKT3 through hsa-miR-206 as a bridge.
Survival: -
Supported No.:
 4
Description:

circ_AKT3 knockdown suppressed cisplatin resistance using miR-206/PTPN14 axis in cisplatin-resistant GC cells.
Other information
Title:

circ_AKT3 knockdown suppresses cisplatin resistance in gastric cancer.

Journal: Open Med (Wars)
Published: 2022/3/3
PubMed ID: 35233464