circRNA basic information
circBase ID: hsa_circ_0020123
Name: -
Synonym: Circ_0020123
Host Gene: hsa-miR-193a-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal lung epithelial cells (BEAS2B) , NSCLC cells (A549,H1299, LTEP-s)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-193a-3p
Biological function: Circ_0020123 knockdown constrained xenograft tumor growth in vivo and curbed cell proliferation, migration, and glycolysis, and accelerated cell apoptosis and autophagy in NSCLC cells in vitro.
Molecular mechanism: circ_0020123 could absorb hsa-miR-193a-3p to regulate IRF4 expression.
Survival: poor
Supported No.:
 9
Description:

Circ_0020123 promoted glycolysis and tumor growth by upregulating IRF4 through sequestering miR-193a-3p in NSCLC, offering a novel mechanism by which circ_0020123 is responsible for the malignancy, autophagy, and glycolysis of NSCLC cells.
Other information
Title:

Circ_0020123 regulates autophagy, glycolysis, and malignancy by upregulating IRF4 through eliminating miR-193a-3p-mediated suppression of IRF4 in non-small cell lung cancer.

Journal: Neoplasma
Published: 2022/3/1
PubMed ID: 35225648