circRNA basic information
circBase ID: -
Name: hsa_circ_EHD2
Synonym: circEHD2
Host Gene: hsa-miR-3186-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Immortalized human bronchial epithelial BEAS-2B, NSCLC cells (A549, H1975, SK-MES-1, H520)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-3186-3p
Biological function: Repressive circEHD2 or enhancive miR-3186-3p facilitated cell apoptosis rate and autophagy substrates LC3BII and Beclin-1, but curbed the colony-formation and DNA replication ability of NSCLC, glucose consumption, lactic acid production, glycolytic rate-limiting enzyme HK-2 and glutamine hydrolase GLS1 and P62, while overexpressed circEHD2 was adverse.
Molecular mechanism: the impacts of repressive and elevated circEHD2 on NSCLC were turned around via reduced hsa-miR-3186-3p or forkhead box k1 (FOXK1) separately. Mechanically, FOXK1 was augmented via circEHD2s competitive integration of hsa-miR-3186-3p
Survival: -
Supported No.:
 1
Description:

circEHD2 accelerates the proliferation and glycolysis of NSCLC, but refrains autophagy and apoptosis via strengthening FOXK1 via the adsorption of miR-3186-3p, which is supposed to be a latent molecular target for NSCLC therapy later.
Other information
Title:

Circular RNA Eps15-homology domain containing protein 2 motivates proliferation, glycolysis but refrains autophagy in non-small cell lung cancer via crosstalk with microRNA-3186-3p and forkhead box K1.

Journal: Bioengineered
Published: 2022/3/1
PubMed ID: 35220908