circRNA basic information
circBase ID: hsa_circ_0008043
Name: -
Synonym: circ_0008043
Host Gene: hsa-miR-326
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HCC cell lines (Hep3B, SNU449, Huh7, Focus, MHCC97H, HA22T, HCCLM3), normal cells (THLE3)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-326
Biological function: Interfering with circ_0008043 suppressed cellular proliferation, migration, invasion, and cell growth.
Molecular mechanism: Circ_0008043 was confirmed to be an hsa-miR-326 sponge that targets RAB21.
Survival: -
Supported No.:
 1
Description:

In summary, silencing of circ_0008043 impeded HCC progression by regulating the miR-326/RAB21 axis. These data suggest that circ_0008043 may have clinical value in the treatment of HCC.
Other information
Title:

Circular RNA Circ_0008043 promotes the proliferation and metastasis of hepatocellular carcinoma cells by regulating the microRNA (miR)-326/RAB21 axis.

Journal: Bioengineered
Published: 2022/3/1
PubMed ID: 35220907