circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: hsa-miR-124, hsa-miR-506
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Liver cancer cell lines (HepG2, SMMC-7721, Bel-7402, Huh-7), a human hepatic cell line (HL7702)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-124, hsa-miR-506
Biological function: we proved that knock down of circHIPK3 remarkably suppressed the proliferation and invasion of HCC cells.
Molecular mechanism: circHIPK3 directly bound to hsa-miR-124 or hsa-miR-506 and inhibited their expression, and PDK2 was a target gene of hsa-miR-124 or hsa-miR-506.
Survival: -
Supported No.:
 6
Description:

We suggest that circHIPK3 can accelerate the proliferation and invasion of HCC cells by sponging miR-124 or miR-506 to upregulate PDK2, which is the underlying mechanism of circHIPK3-induced HCC progression.
Other information
Title:

The novel circular RNA HIPK3 accelerates the proliferation and invasion of hepatocellular carcinoma cells by sponging the micro RNA-124 or micro RNA-506/pyruvate dehydrogenase kinase 2 axis.

Journal: Bioengineered
Published: 2022/2/26
PubMed ID: 35212603