circRNA basic information
circBase ID: hsa_circ_0041268
Name: hsa_circ_PRPF8
Synonym: circ_0041268
Host Gene: hsa-miR-214-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human pulmonary epithelial cell line (BEAS_2B), NSCLC cell lines (H1755, H1650, PC9, A549)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-214-5p
Biological function: sa_circ_0041268 downregulation decreased cell proliferation and migration.
Molecular mechanism: ROCK1 and hsa-miR-214-5p were hsa_circ_0041268 downstream targets.
Survival: -
Supported No.:
 1
Description:

Together, results demonstrated that hsa_circ_0041268 acted as tumor promoter through novel hsa_circ_0041268/miR-214-5p/ROCK1 axis, which highlighted its potential as NSCLC therapeutic agent.
Other information
Title:

Hsa_circ_0041268 promotes NSCLC progress by sponging miR-214-5p/ROCK1.

Journal: J Clin Lab Anal
Published: 2022/2/26
PubMed ID: 35212425