circRNA basic information
circBase ID: hsa_circ_0072309
Name: hsa_circ_LIFR
Synonym: circ_0072309
Host Gene: hsa-miR-100
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: glioblastoma cell lines (U87, A172, U251)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-100
Biological function: he regulation of hsa_circ_0072309 on autophagy and TMZ sensitivity depends on the status of p53.
Molecular mechanism: Hsa_circ_0072309 inhibits p53 ubiquitination and increases the stability of p53 protein in the context of p53 wild-type. hsa-miR-100 mediates hsa_circ_0072309 regulating p53. P53 inhibitor or autophagy inhibitor could reverse the effect of hsa_circ_0072309 on TMZ sensitivity in p53 wild-type GBM.
Survival: better
Supported No.:
 1
Description:

This study revealed a function of hsa_circ_0072309 promoting autophagy by p53 signaling pathway and enhancing TMZ sensitivity. These findings demonstrated that hsa_circ_0072309 may be a potential and promising target in designing the treatment strategy for GBM.
Other information
Title:

Hsa_circ_0072309 enhances autophagy and TMZ sensitivity in glioblastoma.

Journal: CNS Neurosci Ther
Published: 2022/2/26
PubMed ID: 35212145