circRNA basic information
circBase ID: hsa_circ_0001394
Name: hsa_circ_TBC1D14
Synonym: -
Host Gene: hsa-miR-527
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human HCC cell lines (Hep3B, HCCLM3, SMMC7721, MHCC97H, HepG2, Huh7), a normal liver cell line (LO2), 293_T cells
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-527
Biological function: Hsa_circ_0001394 promoted the proliferation, migration, and invasion of HCC cells, whereas knockdown of hsa_circ_0001394 inhibited HCC tumorigenesis in vivo.
Molecular mechanism: mechanistic studies showed that hsa-miR-527 negatively interacted with hsa_circ_0001394. Furthermore, UBE2A was revealed to serve as a target of hsa-miR-527.
Survival: poor
Supported No.:
 2
Description:

The present study suggested that hsa_circ_0001394 may function as a sponge to promote HCC progression by regulating the miR-527/UBE2A pathway. Thus, hsa_circ_0001394 may become a promising biomarker and potential therapeutic target in HCC treatment.
Other information
Title:

The circular RNA hsa_circ_0001394 promotes hepatocellular carcinoma progression by targeting the miR-527/UBE2A axis.

Journal: Cell Death Discov
Published: 2022/2/26
PubMed ID: 35210429