circRNA basic information
circBase ID: -
Name: hsa_circ_SHPRH
Synonym: circSHPRH
Host Gene: hsa-miR-942
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human BCa cell lines (5637, T24, J82, EJ, UM-UC-3 cells), human immortalized uroepithelium cell line (SV-HUC-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-942
Biological function: Cell function studies indicated that silencing circSHPRH dramatically increased the proliferation, migration and invasion of BCa cells. Animal experiments revealed that circSHPRH overexpression repressed tumor growth.
Molecular mechanism: Mechanistic studies demonstrated that circSHPRH could combine with hsa-miR-942 and serve as a sponge of hsa-miR-942, which targets BARX2 in BCa cells.
Survival: -
Supported No.:
 1
Description:

Taken together, our findings indicate that circSHPRH serves as a sponge of miR-942 to inhibit BCa progression by upregulating BARX2 expression, thereby inhibiting the Wnt/beta-catenin signaling pathway.
Other information
Title:

Circular RNA circSHPRH inhibits the malignant behaviors of bladder cancer by regulating the miR-942/BARX2 pathway.

Journal: Aging (Albany NY)
Published: 2022/2/25
PubMed ID: 35200157