circRNA basic information
circBase ID: hsa_circ_0008194
Name: -
Synonym: CircRNA_0008194
Host Gene: hsa-miR-190a
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HCC cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-190a
Biological function: Through knockdown and overexpression of circ_0008194, we conducted in vitro functional studies. We found circ_0008194 could induce the invasion of cells in vitro.
Molecular mechanism: circ_0008194 presented the binding ability with hsa-miR-190a causing the suppression of hsa-miR-190a expression, causing the competitive inhibition of AHNAK, resulting in the promotion of EMT.
Survival: -
Supported No.:
 1
Description:

Our results suggested that circ_0008194 may act as a sponge to adsorb miR-190a, thereby promoting the expression of AHNAK and promoting the metastasis of liver cancer tumors.
Other information
Title:

CircRNA_0008194 functions as a ceRNA to promote invasion of hepatocellular carcinoma via inhibiting miR-190a/AHNAK signaling pathway.

Journal: J Clin Lab Anal
Published: 2022/2/25
PubMed ID: 35199873