circRNA basic information
circBase ID: hsa_circ_0020123
Name: -
Synonym: Circ_0020123
Host Gene: hsa-miR-940
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human non-cancerous lung cell lines (BEAS-2B), NSCLC cell lines (A549, PC9)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-940
Biological function: knockdown of circ_0020123 abolished cell growth, migration and invasion_n vitro_nd hindered tumor growth in nude mice.
Molecular mechanism: circ_0020123 directly targeted hsa-miR-940, and KIAA1522 was a target of hsa-miR-940.
Survival: -
Supported No.:
 9
Description:

In all, circ_0020123 acted as an oncogene to promote the tumorigenesis of NSCLC via miR-940/KIAA1522 axis, suggesting a potential therapeutic target for NSCLC treatment.
Other information
Title:

Circ_0020123 promotes NSCLC tumorigenesis via up-regulating KIAA1522 expression through miR-940.

Journal: Cell Cycle
Published: 2022/2/24
PubMed ID: 35196193