circRNA basic information
circBase ID: hsa_circ_0007059
Name: hsa_circ_ZNF720
Synonym: circ_0007059
Host Gene: hsa-miR-378, hsa-miR-383
 
 
 
Disease basic information
DO ID:
 5844
DO name: myocardial infarction
Disease details: myocardial Infarction
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: cardiomyocytes
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-378, hsa-miR-383
Biological function: circ_0007059 knockdown improved cardiomyocyte viability after H2O2_reatment as revealed by the CCK-8 and colony formation assays. Flow cytometry and caspase activity assays demonstrated that circ_0007059 suppressed H2O2-induced cardiomyocyte apoptosis. Enzyme-linked immunosorbent assays and Western blotting revealed that inflammatory cytokine (interleukin-1beta, interleukin-18 and C-C motif chemokine ligand 5) expression was induced by H2O2_reatment and that circ_0007059 repressed H2O2-induced inflammation.
Molecular mechanism: circ_0000759 acts as a hsa-miR-378 and hsa-miR-383 sponge. Furthermore, the upregulation or suppression of hsa-miR-378 and hsa-miR-383 expression in H2O2-treated cardiomyocytes had similar effects on the apoptosis and inflammation of cardiomyocytes as that of circ_0007059 knockdown or overexpression, respectively.
Survival: -
Supported No.:
 1
Description:

Collectively, our findings suggest that circ_0007059 expression is upregulated in mice cardiomyocytes in response to oxidative stress and cardiac tissues of MI mouse model, suggesting its involvement in the pathogenesis of MI by targeting miR-378 and miR-383.
Other information
Title:

Hsa_circ_0007059 promotes apoptosis and inflammation in cardiomyocytes during ischemia by targeting microRNA-378 and microRNA-383.

Journal: Cell Cycle
Published: 2022/2/23
PubMed ID: 35192424