circRNA basic information
circBase ID: -
Name: hsa_circ_BIRC6
Synonym: circBIRC6
Host Gene: hsa-miR-217
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human bronchial epithelial cell line (16HBE), NSCLC cell lines (A549, H1299)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-217
Biological function: Knockdown of circBIRC6 repressed the colony formation and metastasis and facilitated apoptosis of NSCLC cells in vitro and restrained tumorigenesis in vivo.
Molecular mechanism: circBIRC6 functioned as hsa-miR-217 sponge to promote APPBP2 expression in NSCLC cells. hsa-miR-217 inhibition rescued circBIRC6 knockdown-mediated effects on NSCLC cell colony formation, metastasis, and apoptosis. Overexpression of hsa-miR-217 inhibited the malignant phenotypes of NSCLC cells, while the effects were abrogated by elevating APPBP2.
Survival: -
Supported No.:
 5
Description:

CircBIRC6 aggravated NSCLC cell progression by elevating APPBP2 via sponging miR-217, which might provide a fresh perspective on NSCLC therapy.
Other information
Title:

circBIRC6 contributes to the development of non-small cell lung cancer via regulating microRNA-217/amyloid beta precursor protein binding protein 2 axis.

Journal: Chin Med J (Engl)
Published: 2022/2/23
PubMed ID: 35191420