circRNA basic information
circBase ID: hsa_circ_0001460
Name: hsa_circ_NEIL3
Synonym: circNEIL3
Host Gene: hsa-miR-1184
 
 
 
Disease basic information
DO ID:
 3910
DO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human LUAD cell lines (A549, NCI_H1299)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-1184
Biological function: Functional assays demonstrated that circNEIL3 knockdown promoted radiation-induced cell pyroptosis, whereas circNEIL3 overexpression had the opposite effects. Importantly, the effects of circNEIL3 overexpression on inhibiting pyroptosis were reversed by PIF1 knockdown.
Molecular mechanism: circNEIL3-mediated pyroptosis was achieved through directly binding to hsa-miR-1184 as a sponge, thereby releasing the inhibition of hsa-miR-1184 on PIF1, which ultimately induces DNA damage and triggers AIM2 inflammasome activation. In vivo, circNEIL3 knockdown significantly enhanced the efficacy of radiotherapy as evidenced by decreases in tumor volume and weight.
Survival: -
Supported No.:
 1
Description:

Collectively, the circNEIL3/miR-1184/PIF1 axis that mediate pyroptosis induction may be a novel, promising therapeutic strategy for the clinical treatment of lung cancer.
Other information
Title:

CircNEIL3 mediates pyroptosis to influence lung adenocarcinoma radiotherapy by upregulating PIF1 through miR-1184 inhibition.

Journal: Cell Death Dis
Published: 2022/2/23
PubMed ID: 35190532