circRNA basic information
circBase ID: hsa_circ_0011232
Name: -
Synonym: Circ_0011232
Host Gene: hsa-miR-503-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HCC cells (MHCC97-L), normal cells (MIHA)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-503-5p
Biological function: Circ_0011232 knockdown repressed HCC cell proliferation, colony formation, migration, and invasion, and promoted apoptosis in vitro and blocked tumor growth in vivo.
Molecular mechanism: hsa-miR-503-5p was a target of circ_0011232, AKT3 was confirmed to be a target of hsa-miR-503-5p, and AKT3 overexpression abolished the inhibitory effects on HCC cell progression caused by hsa-miR-503-5p.
Survival: -
Supported No.:
 1
Description:

Circ_0011232 facilitated HCC progression via miR-503-5p/AKT3 axis, which might provide a novel treatment strategy for HCC.
Other information
Title:

Circ_0011232 contributes to hepatocellular carcinoma progression through miR-503-5p/AKT3 axis.

Journal: Hepatol Res
Published: 2022/2/22
PubMed ID: 35187761