circRNA basic information
circBase ID: hsa_circ_0048674
Name: hsa_circ_UHRF1
Synonym: circ_0048674
Host Gene: hsa-miR-223-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: THLE-2 cells .HUVECs, Huh7, HCCLM3 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-223-3p
Biological function: Silencing of hsa_circ_0048674 repressed cell growth, migration, invasion and angiogenesis and promoted apoptosis in HCC cells in vitro and hampered tumor growth in vivo.
Molecular mechanism: Hsa_circ_0048674 served as an hsa-miR-223-3p sponge to alter PDL1 expression.
Survival: -
Supported No.:
 2
Description:

Hsa_circ_0048674 knockdown decelerated HCC progression through the mediation of the miR-223-3p/PDL1 axis.
Other information
Title:

Hsa_circ_0048674 facilitates hepatocellular carcinoma progression and natural killer cell exhaustion depending on the regulation of miR-223-3p/PDL1.

Journal: Histol Histopathol
Published: 2022/2/22
PubMed ID: 35187630