circRNA basic information
circBase ID: -
Name: hsa_circ_ACVR2A
Synonym: circACVR2A
Host Gene: hsa-miR-1290
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human cell (GES-1), human GC cell lines (MKN-45, SNU-1, SGC-7901, HGC-27)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1290
Biological function: The downregulation of circACVR2A promotes GC cell proliferation and metastasis and suppressed the expression level of E-cadherin and Vimentin
Molecular mechanism: The hsa-miR-1290 inhibitor reversed the effect of circACVR2A on cell progression in GC cell.
Survival: -
Supported No.:
 1
Description:

circACVR2A competitively sponged miR-1290 and was exerted as a tumor suppressor gene oncogene via a circACVR2A/miR-1290 axis, suggesting it as a possible biomarker for GC therapy.
Other information
Title:

CircRNA ACVR2A Sponges miR-1290 to Modulate Cell Progression in Gastric Cancer.

Journal: J Oncol
Published: 2022/2/22
PubMed ID: 35186081