circRNA basic information
circBase ID: hsa_circ_0000218
Name: hsa_circ_DCLRE1C
Synonym: circ_0000218
Host Gene: hsa-miR-139-3p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: gastric cancer cell line (AGS), normal gastric epithelial cell line (GES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-139-3p
Biological function: -
Molecular mechanism: circ_0000218 knockdown inhibited GC cell proliferation, promoted apoptosis and enhanced cleaved-Caspase3 expression in GC cells, whereas hsa-miR-139-3p knockdown reversed these effects. hsa-miR-139-3p overexpression inhibited proliferation and induced apoptosis in GC cells, but these effects were reversed by SOX4 overexpression.
Survival: -
Supported No.:
 1
Description:

Collectively, the present study demonstrated that circ_0000218 upregulated SOX4 via downregulating miR-139-3p to promote GC progression.
Other information
Title:

hsa_circ_0000218/hsa-miR-139-3p/SOX4 regulatory feedback circuit influences the proliferation and apoptosis of gastric cancer cells.

Journal: Cytotechnology
Published: 2022/2/22
PubMed ID: 35185288